Hippocampus anatomy dentate gyrus rat crossection

HIPPOCAMPUS ANATOMY DENTATE GYRUS RAT CROSSECTION FULL

Yet, these types of anatomical-scale models are necessary to explore the contributions of topographically organized connectivity on the spatio-temporal dynamics of their respective neural systems.ДЄt a basic level, connectivity determines the spatial arrangement of postsynaptic activation given a presynaptic spike resulting in a correlation across neurons, i.e., a spatially organized correlation.

HIPPOCAMPUS ANATOMY DENTATE GYRUS RAT CROSSECTION FULL

Few computational models of neural systems have attempted to represent their full geometrical, or at least up to an extent at which the mesoscale contributions to population activity can be observed ( Schneider et al., 2012 Markram et al., 2015 Hendrickson et al., 2016 Billeh et al., 2020).

The technical difficulty in recreating these studies with either older or more modern methods limit further characterizations of the microscale and mesoscale topography. This is partly due to the difficulty in interpreting and integrating the results of the key studies, many of which were performed several decades ago, into a single comprehensive model.

Despite a thorough characterization of the macroscale, mesoscale, and microscale connectivity of rat hippocampus, the contributions of the architecture of the afferent and efferent projections to the organization of population dynamics has yet to be fully understood. The architecture and connectivity of rat hippocampus has been intensely studied, revealing a prominent topographic organization within the highly complex and tortuous structure of the hippocampal anatomy. The resulting gradients may provide a basis for the known functional organization observed in hippocampus. The topographic organization of the associational system gave rise to changes in the spatial correlation structure along the longitudinal and transverse axes of the CA3. A correlation map was constructed to characterize the spatial structure and temporal evolution of pairwise correlations which underlie the emergent patterns found in the population activity. Using a large-scale, computational neuronal network model of the entorhinal-dentate-CA3 system, the effects of the perforant path, mossy fibers, and associational system on the propagation and transformation of network spiking patterns were investigated.

The topographic organization of afferents to the hippocampal CA3 subfield are well-studied, but their role in influencing the spatiotemporal dynamics of population activity is not understood. Department of Biomedical Engineering, Center for Neural Engineering, University of Southern California, Los Angeles, CA, United States.

Hippocampus anatomy dentate gyrus rat crossection